cardiac fibrosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11807	L002		Others , Histone Acetyltransferase , STAT
	L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By ...		Others , Histone Acetyltransferase , STAT
T1449	Hydrochlorothiazide	HCTZ	Potassium Channel , Carbonic Anhydrase , TGF-beta/Smad
	Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.		Potassium Channel , Carbonic Anhydrase , TGF-beta/Smad
T3096	Canrenoate potassium	Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone	Glucocorticoid Receptor
	Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity.		Glucocorticoid Receptor
T5247	Trimethylamine N-oxide dihydrate	TMANO Dihydrate	Others , Endogenous Metabolite
	Trimethylamine N-oxide dihydrate (TMANO Dihydrate), a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays.		Others , Endogenous Metabolite
T9010	IMM-H007		Others , AMPK
	IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression		Others , AMPK
T30778	CCG-257081	MRTF/SRF-IN-1,CCG257081,CCG 257081	Rho , Ras
	CCG-257081 (MRTF/SRF-IN-1) is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MRTF/SRF pathway.CCG-257081 has shown efficacy in preventing ...		Rho , Ras
T12078	ML334	LH601A	Nrf2
	ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proli...		Nrf2
T41245	Trimethylamine N-oxide		Reactive Oxygen Species , NOD-like Receptor (NLR) , TGF-beta/Smad
	Trimethylamine N-oxide (TMAO) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in tissues of marine animals and prevents the protein-damaging e...
T3753	Sinapinic Acid	Sinapic acid,Synapoic acid	Apoptosis , RAAS , Reactive Oxygen Species , HDAC
	Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap...		Apoptosis , RAAS , Reactive Oxygen Species , HDAC
T27247	EGFR-IN-542
	EGFR-IN-542 is a novel EGFR inhibitor. EGFR-IN-542 significantly reduces myocardial inflammation, fibrosis, apoptosis and dysfunction. It shows promise for use in the treatment of obesity-induced cardiac complications.
T10554	Bixin		Others
	Bixin is isolated from the seeds of Bixa orellana and possesses anti-tumor, anti-inflammatory, and antioxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation, and RO...		Others
T38424	(R)-Fadrozole	FAD286,(R)-CGS 16949A free base,(R)-Fadrozole
	(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in sp...
T60266	(Rac)-Indoximod
	(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardi...
T60713	TK-129
	TK-129 is an orally active, potent inhibitor of KDM5B with IC 50 of 44 nM that is low-toxicity. TK-129 shows cardioprotective effects by inhibiting KDM5B and blocking the KDM5B -associated Wnt pathway. TK-129 can be used...
T65994	(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
	Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a ...